Restoring brain wiring, mobility, sleep, and lifespan with a novel repurposed modulator of voltage-gated K+ channels: an emerging perspective for channelopathies.

doi:10.1186/s12967-025-07609-6

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Article

Restoring brain wiring, mobility, sleep, and lifespan with a novel repurposed modulator of voltage-gated K+ channels: an emerging perspective for channelopathies.

Journal of translational medicine - 7 Jan 2026

Setzu Maria Dolores, Casu Maria Antonietta, Mocci Ignazia, Talani Giuseppe, Haidar Fatemah M, Sanna Fabrizio, Manis Cristina, Caboni Pierluigi, Bru-Mercier Gilles, Biggio Francesca, Krishnan Manigandan, Muroni Patrizia, Maria Baroli Bianca, Frau Roberto, Concas Luca, Puligheddu Monica, Subramanya Sandeep B, Imbrici Paola, D'Adamo Maria Cristina, Pessia Mauro

Abstract excerpt

BACKGROUND: Voltage-gated K+ channels (Kv) regulate various essential brain functions. Cognitive impairment, intellectual disability, and sleep disruption are prevalent in Kv1.1- and Kv1.2-related channelopathies, yet the mechanistic basis is unresolved and no symptom-specific repurposing candidates for pharmacotherapy have been identified. Furthermore, the role Kv channels play in establishing synaptic...

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PMID: 41501832
DOI: 10.1186/s12967-025-07609-6
PMCID: PMC12910926

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