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Article

Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

Neurobiology of disease - 1 Dec 2010

Fitzgerald Paul J, Barkus Chris, Feyder Michael, Wiedholz Lisa M, Chen Yi-Chyan, Karlsson Rose-Marie, Machado-Vieira Rodrigo, Graybeal Carolyn, Sharp Trevor, Zarate Carlos, Harvey-White Judith, Du Jing, Sprengel Rolf, Gass Peter, Bannerman David, Holmes Andrew

Abstract excerpt

Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities. KO were tested for behavior in approach/avoid conflict tests, responses to repeated forced swim exposure, and locomotor responses under stress and after psychostimulant...

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Identifiers

PMID: 20699120
DOI: 10.1016/j.nbd.2010.08.005
PMCID: PMC2955784

Genes

MARCKS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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