Antagonism of GluK1-containing Kainate Receptors Reduces Ethanol Consumption by Modulating Ethanol Reward and Withdrawal

Abstract excerpt

<h4>ABSTRACT</h4> Alcohol use disorder (AUD) is a neuropsychiatric condition affecting millions of people worldwide. Topiramate (TPM) is an antiepileptic drug that has been shown to reduce ethanol drinking in humans. However, TPM is associated with a variety of adverse effects due to its interaction with many receptor systems and intracellular pathways. Thus, a better understanding of the role of TPM’s main molec...

Topics

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• Adenosine
• Alcoholic Intoxication
• Corpus Striatum
• Cyclic AMP Response Element-Binding Protein
• Excitatory Postsynaptic Potentials
• Nucleus Accumbens
• Organ Culture Techniques
• Patch-Clamp Techniques

Identifiers and source

Literature Corpus work

a6c9d6fb-9bda-5ff8-9f33-1bbc9b79496e

DOI

10.1101/2021.04.24.441015