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Article

A novel murine model of mania

29 Mar 2023

Abstract excerpt

Neuropathological mechanisms of manic syndrome or manic episodes in bipolar disorder remain poorly characterised, as the research progress is severely limited by the paucity of appropriate animal models. Here we developed a novel mania mice model by combining a series of chronic unpredictable rhythm disturbances (CURD), which include disruption of circadian rhythm, sleep deprivation, exposure to cone light, with...

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PMID: 36991130
DOI: 10.1038/s41380-023-02037-8

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