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Article

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.

Scientific reports - 25 Feb 2016

Bøttger Pernille, Glerup Simon, Gesslein Bodil, Illarionova Nina B, Isaksen Toke J, Heuck Anders, Clausen Bettina H, Füchtbauer Ernst-Martin, Gramsbergen Jan B, Gunnarson Eli, Aperia Anita, Lauritzen Martin, Lambertsen Kate L, Nissen Poul, Lykke-Hartmann Karin

Abstract excerpt

Migraine is a complex brain disorder, and understanding the complexity of this prevalent disease could improve quality of life for millions of people. Familial Hemiplegic Migraine type 2 (FHM2) is a subtype of migraine with aura and co-morbidities like epilepsy/seizures, cognitive impairments and psychiatric manifestations, such as obsessive-compulsive disorder (OCD). FHM2 disease-mutations locate to the ATP1A2...

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Identifiers

PMID: 26911348
DOI: 10.1038/srep22047
PMCID: PMC4766516

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