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Article

Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic.

eNeuro - 1 Jan 2000

Kaas Garrett A, Kasuya Junko, Lansdon Patrick, Ueda Atsushi, Iyengar Atulya, Wu Chun-Fang, Kitamoto Toshihiro

Abstract excerpt

Shudderer (Shu) is an X-linked dominant mutation in Drosophila melanogaster identified more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and defects in reactive climbing behavior, and that these phenotypes were significantly suppressed when mutants were fed food containing lithium, a mood stabilizer used in the treatment of bipolar disorder (Williamson, 1982). This unique...

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Identifiers

PMID: 27844061
DOI: 10.1523/ENEURO.0221-16.2016
PMCID: PMC5103163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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