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Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome

19 Sept 2023

Abstract excerpt

BACKGROUND: The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC). METHODS: Protein quantitative trait loci (pQTLs) were derived from seven published genome-wide association studies (GWASs) on plasma proteome, and summary-level data were extracted for 4853...

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PMID: 37726845
DOI: 10.1186/s13073-023-01229-9

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