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Article

Integrating plasma proteomics with genome-wide association data to identify novel drug targets for inflammatory bowel disease.

Scientific reports - 15 Jul 2024

Bai Zhongyuan, Hao Jiawei, Chen Miaoran, Yao Kaixin, Zheng Leilei, Liu Liu, Hu Jingxi, Guo Kaiqing, Lv Yongqiang, Li Feng

Abstract excerpt

Inflammatory bowel disease (IBD) is a chronic disease that includes Crohn's disease (CD) and ulcerative colitis (UC). Although genome-wide association studies (GWASs) have identified many relevant genetic risk loci, the impact of these loci on protein abundance and their potential utility as clinical therapeutic targets remain uncertain. Therefore, this study aimed to investigate the pathogenesis of IBD and...

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Identifiers

PMID: 39009667
DOI: 10.1038/s41598-024-66780-w
PMCID: PMC11250821

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