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Article

Genetics ignite focus on microglial inflammation in Alzheimer's disease.

Molecular neurodegeneration - 5 Oct 2015

Malik Manasi, Parikh Ishita, Vasquez Jared B, Smith Conor, Tai Leon, Bu Guojun, LaDu Mary Jo, Fardo David W, Rebeck G William, Estus Steven

Abstract excerpt

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26438529
DOI: 10.1186/s13024-015-0048-1
PMCID: PMC4595327

Genes

ABCA7
APOE
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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