Article
The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease.
Genes - 20 Mar 2021
Carpanini Sarah M, Harwood Janet C, Baker Emily, Torvell Megan, The Gerad Consortium, Sims Rebecca, Williams Julie, Morgan B Paul
Abstract excerpt
Late-onset Alzheimer's disease (LOAD), the most common cause of dementia, and a huge global health challenge, is a neurodegenerative disease of uncertain aetiology. To deliver effective diagnostics and therapeutics, understanding the molecular basis of the disease is essential. Contemporary large genome-wide association studies (GWAS) have identified over seventy novel genetic susceptibility loci for LOAD. Most...
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