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Article

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome.

Aging cell - 1 Oct 2023

Crochemore Clément, Chica Claudia, Garagnani Paolo, Lattanzi Giovanna, Horvath Steve, Sarasin Alain, Franceschi Claudio, Bacalini Maria Giulia, Ricchetti Miria

Abstract excerpt

Cockayne syndrome (CS) and UV-sensitive syndrome (UVSS) are rare genetic disorders caused by mutation of the DNA repair and multifunctional CSA or CSB protein, but only CS patients display a progeroid and neurodegenerative phenotype, providing a unique conceptual and experimental paradigm. As DNA methylation (DNAm) remodelling is a major ageing marker, we performed genome-wide analysis of DNAm of fibroblasts from...

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PMID: 37688320
DOI: 10.1111/acel.13959
PMCID: PMC10577576

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