Article

Dynamic Regulation OF The Chromatin Environment By Ash1L Modulates Human Neuronal Structure And Function

2024-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Precise regulation of the chromatin environment through post-translational histone modification modulates transcription and controls brain development. Not surprisingly, mutations in a large number of histone-modifying enzymes underlie complex brain disorders. In particular, the histone methyltransferase ASH1L modifies histone marks linked to transcriptional activation and has been implicated in...

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Literature Corpus work: e458f1e7-2434-5d6d-9d55-2d217eddc4e0
DOI: 10.1101/2024.12.02.625500

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