Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data.

Genome biology - 13 Feb 2023

Ma Shiyang, Wang Chen, Khan Atlas, Liu Linxi, Dalgleish James, Kiryluk Krzysztof, He Zihuai, Ionita-Laza Iuliana

Abstract excerpt

We propose BIGKnock (BIobank-scale Gene-based association test via Knockoffs), a computationally efficient gene-based testing approach for biobank-scale data, that leverages long-range chromatin interaction data, and performs conditional genome-wide testing via knockoffs. BIGKnock can prioritize causal genes over proxy associations at a locus. We apply BIGKnock to the UK Biobank data with 405,296 participants for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Genetic Testing

Share to Genome-Wide Association Study

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36782330
DOI: 10.1186/s13059-023-02864-6
PMCID: PMC9926792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data.PMID 36782330Read ↗

Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes.Semantic proximity Read ↗

Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypesSemantic proximity Read ↗

Functionally informed fine-mapping and polygenic localization of complex trait heritability.Semantic proximity Read ↗

Summary statistics knockoff inference empowers identification of putative causal variants in genome-wide association studiesSemantic proximity Read ↗

Estimation of Non-null SNP Effect Size Distributions Enables the Detection of Enriched Genes Underlying Complex TraitsSemantic proximity Read ↗

Multi-resolution localization of causal variants across the genome.Semantic proximity Read ↗

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics.Semantic proximity Read ↗

Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits.Semantic proximity Read ↗

GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies.Semantic proximity Read ↗

Identification of putative causal loci in whole-genome sequencing data via knockoff statisticsSemantic proximity Read ↗

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity.Semantic proximity Read ↗

Knockoff procedure improves susceptibility gene identifications in conditional transcriptome-wide association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.