Article

Estimation of Non-null SNP Effect Size Distributions Enables the Detection of Enriched Genes Underlying Complex Traits

2019-04-02

Abstract excerpt

Traditional univariate genome-wide association studies generate false positives and negatives due to difficulties distinguishing associated variants from variants with spurious nonzero effects that do not directly influence the trait. Recent efforts have been directed at identifying genes or signaling pathways enriched for mutations in quantitative traits or case-control studies, but these can be computationally c...

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Literature Corpus work: 488d34f3-54bf-55cc-b5b4-b291554755f5
DOI: 10.1101/597484

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