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Article

Estimation of non-null SNP effect size distributions enables the detection of enriched genes underlying complex traits.

PLoS genetics - 1 Jun 2020

Cheng Wei, Ramachandran Sohini, Crawford Lorin

Abstract excerpt

Traditional univariate genome-wide association studies generate false positives and negatives due to difficulties distinguishing associated variants from variants with spurious nonzero effects that do not directly influence the trait. Recent efforts have been directed at identifying genes or signaling pathways enriched for mutations in quantitative traits or case-control studies, but these can be computationally...

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PMID: 32542026
DOI: 10.1371/journal.pgen.1008855
PMCID: PMC7316356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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