Article
Identification of putative causal loci in whole-genome sequencing data via knockoff statistics.
Nature communications - 25 May 2021
He Zihuai, Liu Linxi, Wang Chen, Le Guen Yann, Lee Justin, Gogarten Stephanie, Lu Fred, Montgomery Stephen, Tang Hua, Silverman Edwin K, Cho Michael H, Greicius Michael, Ionita-Laza Iuliana
Abstract excerpt
The analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for testing. We propose a statistical method to detect and localize rare and common risk variants in whole-genome sequencing studies based on a recently developed knockoff framework. It can (1) prioritize causal variants over associations due to linkage...
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