Article
Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes.
Proceedings of the National Academy of Sciences of the United States of America - 23 Nov 2021
Ma Shiyang, Dalgleish James, Lee Justin, Wang Chen, Liu Linxi, Gill Richard, Buxbaum Joseph D, Chung Wendy K, Aschard Hugues, Silverman Edwin K, Cho Michael H, He Zihuai, Ionita-Laza Iuliana
Abstract excerpt
Gene-based tests are valuable techniques for identifying genetic factors in complex traits. Here, we propose a gene-based testing framework that incorporates data on long-range chromatin interactions, several recent technical advances for region-based tests, and leverages the knockoff framework for synthetic genotype generation for improved gene discovery. Through simulations and applications to genome-wide...
Topics
- Chromatin
- Genetic Testing
- Genome-Wide Association Study
- Genotype
- Humans
- Japan
- Linkage Disequilibrium
- Lung
- Models, Genetic
- Phenotype