Article

Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes

2021-07-18

Abstract excerpt

Gene-based tests are valuable techniques for identifying genetic factors in complex traits. Here we propose a novel gene-based testing framework that incorporates data on long-range chromatin interactions, several recent technical advances for region-based tests, and leverages the knockoff framework for synthetic genotype generation for improved gene discovery. Through simulations and applications to GWAS and whol...

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Literature Corpus work: 0e4f4561-684b-5b71-99e9-72f406eb9c92
DOI: 10.1101/2021.07.14.21260405

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