Article
GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies.
Nature communications - 23 Nov 2022
He Zihuai, Liu Linxi, Belloy Michael E, Le Guen Yann, Sossin Aaron, Liu Xiaoxia, Qi Xinran, Ma Shiyang, Gyawali Prashnna K, Wyss-Coray Tony, Tang Hua, Sabatti Chiara, Candès Emmanuel, Greicius Michael D, Ionita-Laza Iuliana
Abstract excerpt
Recent advances in genome sequencing and imputation technologies provide an exciting opportunity to comprehensively study the contribution of genetic variants to complex phenotypes. However, our ability to translate genetic discoveries into mechanistic insights remains limited at this point. In this paper, we propose an efficient knockoff-based method, GhostKnockoff, for genome-wide association studies (GWAS)...
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