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Article

Knockoff procedure improves susceptibility gene identifications in conditional transcriptome-wide association studies.

American journal of human genetics - 2 Oct 2025

Zhang Xiangyu, Wang Lijun, Zhao Jia, Zhao Hongyu

Abstract excerpt

Transcriptome-wide association studies (TWASs) have been developed to identify candidate genes associated with complex traits by integrating genome-wide association studies (GWASs) with expression quantitative trait loci (eQTL) data. However, most existing TWAS methods assess the marginal association between a single gene and a trait of interest, ignoring the influence of other genes in the same genomic region....

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Identifiers

PMID: 40902598
DOI: 10.1016/j.ajhg.2025.08.007
PMCID: PMC12412983

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