Multi-resolution localization of causal variants across the genome.

Abstract excerpt

In the statistical analysis of genome-wide association data, it is challenging to precisely localize the variants that affect complex traits, due to linkage disequilibrium, and to maximize power while limiting spurious findings. Here we report on KnockoffZoom: a flexible method that localizes causal variants at multiple resolutions by testing the conditional associations of genetic segments of decreasing width,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Datasets as Topic
• Share to Feasibility Studies