Article

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

2021-03-09

Abstract excerpt

The analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for testing. We propose a statistical method to detect and localize rare and common risk variants in whole-genome sequencing studies based on a recently developed knockoff framework. It can (1) prioritize causal variants over associations due to linkage disequil...

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Literature Corpus work: cd920787-22a9-5d96-aedf-82dadea4bed2
DOI: 10.1101/2021.03.08.434451

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