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Article

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

2 Feb 2023

Abstract excerpt

Abstract Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here report on a human antigen-specific ex vivo model to explore new therapeutic options for T cell immunotherapies. T cells generated with this model resemble tumor-infiltrating exhausted T cells on a phenotypic and transcriptional level. Using a targeted pooled CRISPR-Cas9 screen and individual gene knockout validation...

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PMID: 36732507
DOI: 10.1038/s41467-022-35583-w

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