Article

Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

2025-08-24

Abstract excerpt

Cytotoxic CD8 + T-cells play central roles in tumor immunotherapy. Understanding mechanisms that regulate development, differentiation, and functions of cytotoxic CD8 + T-cells leads to development of better immunotherapies. By combining primary T-cell culture and a syngeneic mouse tumor model with both genome-wide and custom CRISPR/Cas9 screenings, we systematically identified genes and pathways that regulate P...

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Literature Corpus work: 93ec7ffd-3913-54af-8263-c91f3f1d1b22
DOI: 10.1101/2025.08.20.671236

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