Article

Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing

2025-09-19

Abstract excerpt

Natural killer (NK) cell-based immunotherapies represent a promising avenue for cancer treatment due to their ability to eliminate cancer cells independently of antigen presentation and potential for “off-the-shelf” use. However, the molecular determinants governing tumor cell susceptibility to NK cell-mediated cytotoxicity remain incompletely understood. Here we employed CRISPR activation (CRISPRa) screening to s...

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Literature Corpus work: a2705f4a-48d0-5f52-9b00-895f6cfee79b
DOI: 10.1101/2025.09.17.676710

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