Article

CRISPR screens establish regulatory maps of immunosuppressive surface molecules in cancer

2026-03-11

Abstract excerpt

Cancer cells can evade immune surveillance by triggering inhibitory checkpoint responses in tumor-associated T cells through the expression of immunosuppressive surface molecules. While therapeutic blockade of such receptors has emerged as a pillar of cancer therapy, tumor cell-intrinsic mechanisms controlling their expression remain incompletely understood. Fluorescence-activated cell sorting (FACS)-based genetic...

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Literature Corpus work: 6a93915e-0846-57cd-8945-9500d620f629
DOI: 10.64898/2026.03.10.710555

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