Article

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors

2025-09-24

Abstract excerpt

Large-scale CRISPR screening in human T cells holds significant promise for identifying genetic modifications that can enhance cellular immunotherapy. However, many genetic regulators of T cell performance in solid tumors may not be readily revealed in vitro. In vivo screening in tumor-bearing mice offers greater physiological relevance, but has historically been limited by low intratumoral T cell recovery. Here,...

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Identifiers and source

Literature Corpus work: 89cfb290-fab9-59cb-a388-90f70881b835
DOI: 10.1101/2025.09.23.678127

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