Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro modeling of CD8 + T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40

4 Aug 2023

Abstract excerpt

Identifying molecular mechanisms of exhausted CD8 T cells (T ex ) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of in vivo T ex can be costly and inefficient. In vitro models of T ex are easily customizable and quickly generate high cellular yield, enabling CRISPR screening and other high-throughput assays. We established an in vitro model of chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37595022
DOI: 10.1126/sciimmunol.ade3369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro modeling of CD8 + T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40PMID 37595022Read ↗

<i>In Vitro</i> Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40Semantic proximity Read ↗

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell functionSemantic proximity Read ↗

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistenceSemantic proximity Read ↗

A unified atlas of CD8 T cell dysfunctional states in cancer and infectionSemantic proximity Read ↗

Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screensSemantic proximity Read ↗

Precision CRISPR annotation of the functional enhancer landscape in primary human T cellsSemantic proximity Read ↗

Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functionsSemantic proximity Read ↗

The current state and future of T-cell exhaustion researchSemantic proximity Read ↗

T Cell ExhaustionSemantic proximity Read ↗

LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signalingSemantic proximity Read ↗

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell statesSemantic proximity Read ↗

<i>Sleeping Beauty</i> mutagenesis identifies <i>BACH2</i> and other regulators of CD8 <sup>+</sup> T cell exhaustion, persistence <i>in vivo</i> , and CAR-T function under tumor-associated chronic antigen stimulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.