Article
Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.
Genome medicine - 24 Jan 2023
Xin Junyi, Du Mulong, Gu Dongying, Jiang Kewei, Wang Mengyun, Jin Mingjuan, Hu Yeting, Ben Shuai, Chen Silu, Shao Wei, Li Shuwei, Chu Haiyan, Zhu Linjun, Li Chen, Chen Kun, Ding Kefeng, Zhang Zhengdong, Shen Hongbing, Wang Meilin
Abstract excerpt
BACKGROUND: The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their accurate extrapolation to other populations. Here, we aimed to generate a PRS by incorporating East Asian (EAS) and EUR ancestry groups and validate its utility for colorectal cancer risk...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.