Article
Optimizing colorectal cancer screening through polygenic risk score-based risk stratification: evidence from a population-based cohort and screening trial.
Genome medicine - 19 Mar 2026
Chen Hongda, Si Jiahui, Luo Chenyu, Tian Jianbo, Xin Junyi, Yu Canqing, Sun Dianjianyi, Pei Pei, Yang Ling, Millwood Iona Y, Walters Robin G, Chen Yiping, Du Huaidong, Chen Zhengming, Li Liming, Koido Masaru, Kamatani Yoichiro, Wang Meilin, Miao Xiaoping, Lv Jun, Dai Min
Abstract excerpt
BACKGROUND: Accurate risk stratification of colorectal cancer (CRC) is essential for precise screening. Polygenic risk scores (PRS) hold promise for improving predictive efficacy in CRC. However, the real-world applicability of a risk-adapted CRC screening strategy based on the PRS remains underexplored. Therefore, we aimed to evaluate the optimized PRS in a large prospective cohort in China and assess its...
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