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Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies.

Genome medicine - 13 Jun 2024

Tian Jianbo, Zhang Ming, Zhang Fuwei, Gao Kai, Lu Zequn, Cai Yimin, Chen Can, Ning Caibo, Li Yanmin, Qian Sangni, Bai Hao, Liu Yizhuo, Zhang Heng, Chen Shuoni, Li Xiangpan, Wei Yongchang, Li Bin, Zhu Ying, Yang Jinhua, Jin Mingjuan, Miao Xiaoping, Chen Kun

Abstract excerpt

BACKGROUND: Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking for personalized CRC early screening in East Asian (EAS) population. We aimed to develop, validate, and optimize a comprehensive risk prediction model across all stages of the dynamic adenoma-carcinoma sequence in...

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PMID: 38872215
DOI: 10.1186/s13073-024-01355-y
PMCID: PMC11170922

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