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Article

Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.

International journal of cancer - 15 Nov 2022

Ping Jie, Yang Yaohua, Wen Wanqing, Kweon Sun-Seog, Matsuda Koichi, Jia Wei-Hua, Shin Aesun, Gao Yu-Tang, Matsuo Keitaro, Kim Jeongseon, Kim Dong-Hyun, Jee Sun Ha, Cai Qiuyin, Chen Zhishan, Tao Ran, Shin Min-Ho, Tanikawa Chizu, Pan Zhi-Zhong, Oh Jae Hwan, Oze Isao, Ahn Yoon-Ok, Jung Keum Ji, Ren Zefang, Shu Xiao-Ou, Long Jirong, Zheng Wei

Abstract excerpt

Several polygenic risk scores (PRSs) have been developed to predict the risk of colorectal cancer (CRC) in European descendants. We used genome-wide association study (GWAS) data from 22 702 cases and 212 486 controls of Asian ancestry to develop PRSs and validated them in two case-control studies (1454 Korean and 1736 Chinese). Eleven PRSs were derived using three approaches: GWAS-identified CRC risk SNPs, CRC...

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Identifiers

PMID: 35765848
DOI: 10.1002/ijc.34194
PMCID: PMC9509464

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