Article
Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study.
Journal of the National Cancer Institute - 11 Apr 2022
Archambault Alexi N, Jeon Jihyoun, Lin Yi, Thomas Minta, Harrison Tabitha A, Bishop D Timothy, Brenner Hermann, Casey Graham, Chan Andrew T, Chang-Claude Jenny, Figueiredo Jane C, Gallinger Steven, Gruber Stephen B, Gunter Marc J, Guo Feng, Hoffmeister Michael, Jenkins Mark A, Keku Temitope O, Le Marchand Loïc, Li Li, Moreno Victor, Newcomb Polly A, Pai Rish, Parfrey Patrick S, Rennert Gad, Sakoda Lori C, Lee Jeffrey K, Slattery Martha L, Song Mingyang, Win Aung Ko, Woods Michael O, Murphy Neil, Campbell Peter T, Su Yu-Ru, Lansdorp-Vogelaar Iris, Peterse Elisabeth F P, Cao Yin, Zeleniuch-Jacquotte Anne, Liang Peter S, Du Mengmeng, Corley Douglas A, Hsu Li, Peters Ulrike, Hayes Richard B
Abstract excerpt
BACKGROUND: The incidence of colorectal cancer (CRC) among individuals aged younger than 50 years has been increasing. As screening guidelines lower the recommended age of screening initiation, concerns including the burden on screening capacity and costs have been recognized, suggesting that an individualized approach may be warranted. We developed risk prediction models for early-onset CRC that incorporate an...
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