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Article

Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.

JNCI cancer spectrum - 9 May 2026

Klinkhammer Hannah, Spier Isabel, Perne Claudia, Hoffmann Per, Büttner Reinhard, Schröck Evelin, Redler Silke, Jahn Arne, Franke Marcus, Möslein Gabriela, Kloor Matthias, Schmidt Börge, Vangala Deepak, Nguyen Huu Phuc, Forstner Andreas J, Steinke-Lange Verena, Holinski-Feder Elke, Hüneburg Robert, Maj Carlo, Engel Christoph, Mayr Andreas, Aretz Stefan

Abstract excerpt

OBJECTIVE: This study investigates how a polygenic risk score (PRS) influences colorectal cancer (CRC) risk across clinically and molecularly defined risk groups. METHODS: In total, 1839 European-descendant individuals were stratified according to low (<20%), intermediate (20% to 80%), or high (>80%) PRS, based on 93 CRC-associated single-nucleotide polymorphisms (SNPs), for 4 high-risk groups: (i) Lynch syndrome...

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Source

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Identifiers

PMID: 41975491
DOI: 10.1093/jncics/pkag041
PMCID: PMC13263116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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