Genome wide association analysis and association of genetic risk and lifestyle with upper gastrointestinal cancer among an endoscopy-screened cohort in China.

doi:10.1016/j.scib.2026.03.059

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Article

Genome wide association analysis and association of genetic risk and lifestyle with upper gastrointestinal cancer among an endoscopy-screened cohort in China.

Science bulletin - 15 May 2026

He Feifan, Ran Xianhui, Jiang Hao, Fan Zhiyuan, Zhang Yueying, Wang Jinwu, Hao Changqing, Song Guohui, Gong Yanwei, Li Yanyan, Li Xinqing, Chen Ru, Zhang Haoyu, Camargo M Constanza, Abnet Christian C, Wang Shaoming, Wei Wenqiang

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) are influenced by genetic and lifestyle factors. We quantified genetic, lifestyle, and joint effects on upper gastrointestinal (UGI) cancer and evaluated the clinical utility of polygenic risk scores (PRS) for risk stratification. We included 5556 participants from a prospective endoscopy-screened cohort in high-risk regions (Linzhou, Cixian, and...

Topics

Humans
Genome-Wide Association Study
Female
China
Male
Middle Aged
Esophageal Neoplasms
Genetic Risk Score
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Life Style

Stomach Neoplasms

Esophageal Squamous Cell Carcinoma

Risk Factors

Prospective Studies

Aged

Gastrointestinal Neoplasms

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41963194
DOI: 10.1016/j.scib.2026.03.059
PMCID: PMC13180336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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