Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemia

29 Dec 2017

Abstract excerpt

Cohesin complex is a multimeric protein complex, composed of four core subunits, including SMC1A, SMC3, RAD21, and either STAG1 or STAG2 proteins. They form a ring-shaped structure, and mediate sister chromatid cohesion and segregation during mitosis and meiosis. Recently, the cohesin gene mutations have been reported in myeloid neoplasms 1 , 2 , 3 , 4 , 5 , 6 , 7 , but studies regarding their clinical and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Lymphoma Diagnosis and Treatment
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29288251
DOI: 10.1038/s41408-017-0022-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic impacts and dynamic changes of cohesin complex gene mutations in de novo acute myeloid leukemiaPMID 29288251Read ↗

Cohesin mutations in myeloid malignancies.Semantic proximity Read ↗

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.Semantic proximity Read ↗

Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome.Semantic proximity Read ↗

Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes.Semantic proximity Read ↗

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.Semantic proximity Read ↗

Cohesin mutations in acute myeloid leukemia.Semantic proximity Read ↗

Cohesin gene mutations in tumorigenesis: from discovery to clinical significance.Semantic proximity Read ↗

Genetic alterations of the cohesin complex genes in myeloid malignancies.Semantic proximity Read ↗

RAD21 mutations in acute myeloid leukemia.Semantic proximity Read ↗

Cohesin mutations in myeloid malignancies made simple.Semantic proximity Read ↗

Cohesin Mutations in Myeloid Malignancies.Semantic proximity Read ↗

Untangling the loops of STAG2 mutations in myelodysplastic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.