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Article

Genetic alterations of the cohesin complex genes in myeloid malignancies.

Blood - 11 Sept 2014

Thota Swapna, Viny Aaron D, Makishima Hideki, Spitzer Barbara, Radivoyevitch Tomas, Przychodzen Bartlomiej, Sekeres Mikkael A, Levine Ross L, Maciejewski Jaroslaw P

Abstract excerpt

Somatic cohesin mutations have been reported in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). To account for the morphologic and cytogenetic diversity of these neoplasms, a well-annotated cohort of 1060 patients with myeloid malignancies including MDS (n = 386), myeloproliferative neoplasms (MPNs) (n = 55), MDS/MPNs (n = 169), and AML (n = 450) were analyzed for cohesin gene mutational status,...

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Topics

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Share to Chromosomal Proteins, Non-Histone
Share to Cohesins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Disease-Free Survival

Share to Genes, Neoplasm

Share to Leukemia, Myeloid, Acute

Share to Myeloproliferative Disorders

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Source

Open in PubMed Open full text

Identifiers

PMID: 25006131
DOI: 10.1182/blood-2014-04-567057
PMCID: PMC4162108

Genes

STAG2
ASXL1
BCOR
RAD21
RUNX1
SMC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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