Article
Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes.
Leukemia - 1 Sept 2024
Jann Johann-Christoph, Hergott Christopher B, Winkler Marisa, Liu Yiwen, Braun Benjamin, Charles Anne, Copson Kevin M, Barua Shougat, Meggendorfer Manja, Nadarajah Niroshan, Shimony Shai, Winer Eric S, Wadleigh Martha, Stone Richard M, DeAngelo Daniel J, Garcia Jacqueline S, Haferlach Torsten, Lindsley R Coleman, Luskin Marlise R, Stahl Maximilian, Tothova Zuzana
Abstract excerpt
Mutations in the cohesin complex components (STAG2, RAD21, SMC1A, SMC3, and PDS5B) are recurrent genetic drivers in myelodysplastic neoplasm (MDS) and acute myeloid leukemia (AML). Whether the different cohesin subunit mutations share clinical characteristics and prognostic significance is not known. We analyzed 790 cohesin-mutant patients from the Dana-Farber Cancer Institute (DFCI) and the Munich Leukemia...
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