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SARS-CoV-2 evolution influences GBP and IFITM sensitivity

24 Jan 2023

Abstract excerpt

SARS-CoV-2 spike requires proteolytic processing for viral entry. A polybasic furin-cleavage site (FCS) in spike, and evolution toward an optimized FCS by dominant variants of concern (VOCs), are linked to enhanced infectivity and transmission. Here we show interferon-inducible restriction factors Guanylate-binding proteins (GBP) 2 and 5 interfere with furin-mediated spike cleavage and inhibit the infectivity of...

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PMID: 36693093
DOI: 10.1073/pnas.2212577120

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