Article

SARS-CoV-2 Variants of Concern Have Acquired Mutations Associated With an Increased Spike Cleavage

2021-09-03

Abstract excerpt

Several SARS-CoV-2 lineages have emerged leading to the divergence of more transmissible variants termed Variants of Concern (VOCs). The natural selection of mutations in the spike protein can impact viral cell entry, transmission, and pathogenesis. Here, we characterized emerging SARS-CoV-2 spike polymorphisms <i>in vitro</i> and <i>in vivo</i> to demonstrate that the substitution S:655Y, included in the highly p...

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Literature Corpus work: 0fcfa725-ff4d-5219-a9e9-a17b6d20bf22
DOI: 10.2139/ssrn.3915655

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