Article

Pre-pandemic artificial MERS analog of pathogenic polyfunctional SARS-CoV-2 S1/S2 furin cleavage site domain is unique among betacoronaviruses

2024-04-22

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 spike (S) glycoprotein furin cleavage site is a key determinant of SARS-CoV-2 virulence and COVID-19 pathogencity. Located at the S1/S2 junction, it is unique among sarbecoviruses but frequently found among betacoronaviruses. Recent evidence suggests that this site includes two additional functional motifs: a pat7 nuclear localization signal and two flanking O-glycosites. How...

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Literature Corpus work: d156206b-eac4-517d-ad65-1250e2e103c3
DOI: 10.21203/rs.3.rs-4282844/v1

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