Article

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

2020-08-26

Abstract excerpt

SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world. Sequence analysis indicates that the novel coronavirus (CoV) has an insertion of a furin cleavage site (PRRAR) in its spike protein. Absent in other group 2B CoVs, the insertion may be a key factor in the replication and virulence of SARS-CoV-2. To explore this question, we generated a SARS-CoV-2 mutant lacking the furin cleavage...

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Literature Corpus work: 02ec52b9-3d64-5c77-a0d1-3b4e93054e3c
DOI: 10.1101/2020.08.26.268854

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