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Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence

28 Jul 2020

Abstract excerpt

The COVID-19 pandemic is an urgent global health emergency, and the presence of Furin site in the SARS-CoV-2 spike glycoprotein alters virulence and warrants further molecular, structural, and biophysical studies. Here we report the structure of Furin in complex with SARS-CoV-2 spike glycoprotein, demonstrating how Furin binds to the S1/S2 region of spike glycoprotein and eventually cleaves the viral protein...

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PMID: 32787225
DOI: 10.1021/acs.jpclett.0c01698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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