Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity

1 Aug 2022

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remains poorly characterized despite enrichment of mutations in this region across variants of concern (VOCs). Here, we examine the contribution of the NTD to infection and cell-cell fusion by constructing chimeric spikes bearing B.1.617 lineage (Delta and Kappa variants) NTDs and generating spike pseudotyped...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Outbreaks Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35963244
DOI: 10.1016/j.celrep.2022.111220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicityPMID 35963244Read ↗

Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effectsSemantic proximity Read ↗

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variantSemantic proximity Read ↗

SARS-CoV-2 Variants of Concern Have Acquired Mutations Associated With an Increased Spike CleavageSemantic proximity Read ↗

Domains and Functions of Spike Protein in Sars-Cov-2 in the Context of Vaccine Design.Semantic proximity Read ↗

Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of SpikeSemantic proximity Read ↗

Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry.Semantic proximity Read ↗

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell typesSemantic proximity Read ↗

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant.Semantic proximity Read ↗

SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.Semantic proximity Read ↗

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.Semantic proximity Read ↗

SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 VirusSemantic proximity Read ↗

SARS-CoV-2 Delta Spike Protein Enhances the Viral Fusogenicity and Inflammatory Cytokine ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.