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Adaptive variations in SARS-CoV-2 spike proteins: effects on distinct virus-cell entry stages

29 Jun 2023

Abstract excerpt

Evolved SARS-CoV-2 variants of concern (VOCs) spread through human populations in succession. Major virus variations are in the entry-facilitating viral spike (S) proteins; Omicron VOCs have 29-40 S mutations relative to ancestral D614G viruses. The impacts of this Omicron divergence on S protein structure, antigenicity, cell entry pathways, and pathogenicity have been extensively evaluated, yet gaps remain in...

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PMID: 37382441
DOI: 10.1128/mbio.00171-23

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