Article
Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity.
Nature communications - 16 May 2024
Wang Shengjun, Ran Wei, Sun Lingyu, Fan Qingchi, Zhao Yuanqi, Wang Bowen, Yang Jinghong, He Yuqi, Wu Ying, Wang Yuanyuan, Chen Luoyi, Chuchuay Arpaporn, You Yuyu, Zhu Xinhai, Wang Xiaojuan, Chen Ye, Wang Yanqun, Chen Yao-Qing, Yuan Yanqiu, Zhao Jincun, Mao Yang
Abstract excerpt
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein is a hallmark of SARS-CoV-2 and plays a crucial role in viral infection. However, the mechanism underlying furin activation and its regulation remain poorly understood. Here, we show that GalNAc-T3 and T7 jointly initiate clustered O-glycosylations in the furin cleavage site of the SARS-CoV-2 spike protein, which inhibit furin...
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