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The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2

6 Nov 2021

Abstract excerpt

Compared with other SARS-related coronaviruses (SARSr-CoVs), SARS-CoV-2 possesses a unique furin cleavage site (FCS) in its spike. This has stimulated discussion pertaining to the origin of SARS-CoV-2 because the FCS has been observed to be under strong selective pressure in humans and confers the enhanced ability to infect some cell types and induce cell-cell fusion. Furthermore, scientists have demonstrated...

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PMID: 34788836
DOI: 10.1093/molbev/msab327

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