Article

Sequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection

2023-06-08

Abstract excerpt

<title>Abstract</title> <p>The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a hallmark of SARS-CoV-2 and is essential for its increased infectivity. O-glycosylation near the furin site catalyzed by host cell glycosyltransferases can theoretically hinder spike protein processing and impede viral infection, but so far such hypothesis has not been tested with authentic vir...

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Literature Corpus work: d0f09ce6-5ae6-5265-8143-23b04e214c28
DOI: 10.21203/rs.3.rs-2703199/v1

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