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Article

Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans.

Molecular biology and evolution - 4 Jan 2023

Todd Robert T, Soisangwan Natthapon, Peters Sam, Kemp Bailey, Crooks Taylor, Gerstein Aleeza, Selmecki Anna

Abstract excerpt

Invasive fungal infections are a leading global cause of human mortality. Only three major classes of antifungal drugs are widely used, and resistance to all three classes can arise rapidly. The most widely prescribed antifungal drug, fluconazole, disseminates rapidly and reaches a wide range of concentrations throughout the body. The impact of drug concentration on the spectrum and effect of mutations acquired...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36649220
DOI: 10.1093/molbev/msad009
PMCID: PMC9887641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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