Article

Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomes

2022-12-02

Abstract excerpt

Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the minimum inhibitory drug concentration (MIC). Here we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature-enhanced tolerance at 37°C and 39°C, and were not tolerant at 30°C. Other isolates were either always tolerant (23.3%) or...

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Literature Corpus work: 38d4953a-81d8-5e22-8014-79b1a802eaf0
DOI: 10.1101/2022.11.30.518455

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